LRIG-inhibitors of growth factor signalling - double-edged swords in human cancer?

被引：84

作者：

Hedman, Hakan ^{[1
]}

Henriksson, Roger ^{[1
]}

机构：

[1] Umea Univ, Dept Radiat Sci, SE-90187 Umea, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 04期

关键词：

LRIG; EGFR; ErbB; tumour suppressor; receptor tyrosine kinase;

D O I：

10.1016/j.ejca.2006.10.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins are newly discovered negative regulators of growth factor signalling and proposed tumour suppressors. They antagonise signalling by interacting with growth factor receptors and by enhancing their ubiquitylation and degradation. Data on the expression of LRIG in human cancer have recently begun to accumulate; however, not all data appear consistent with the notion that the LRIG proteins always function as tumour suppressors. in the present review, we argue that the LRIG proteins could be double-edged swords, promoting or suppressing human cancer depending on cellular context. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：676 / 682

页数：7

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