HIV and the CCR5-Δ32 resistance allele

被引：70

作者：

de Silva, E ^{[1
]}

Stumpf, MPH ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, London SW7 2AZ, England

来源：

FEMS MICROBIOLOGY LETTERS | 2004年 / 241卷 / 01期

关键词：

chemokines; host-virus interactions; population genetics;

D O I：

10.1016/j.femsle.2004.09.040

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combination of molecular biology, epidemiology, virology, evolutionary and population genetics has enabled us to understand the delicate interplay between HIV and the CCR5-Delta32 HIV resistance allele. We here review and collect from the different approaches to show how they can be combined to elucidate the interaction between host and pathogen genetics in this system. We will present an overview of the normal role of CCR5, its involvement in HIV, the molecular biology of the CCR5-Delta\32 allele and its probable origins. By focusing on this well-documented and important system we hope to demonstrate the power that such a "holistic" approach might offer in the study of infectious diseases. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1 / 12

页数：12

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