Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses

Single 130 fs laser pulses in the near-IR (800 nm) were used to create ophthalmoscopically viewed minimum visible lesions (MVLs) within the macular and paramacular regions in rhesus monkey eyes. MVL thresholds at 1 and 24 h are reported as the 50% probability for damage (ED50) together with their fiducial limits at the 95% confidence level. These measured thresholds are compared with previously reported thresholds for near-IR and visible wavelengths for both macular and paramacular areas. Threshold doses were lower at the 24 h reading than at the 1 h reading for both retinal regions and the ED(50)s for the macula were slightly lower than for the paramacula. We measured the 24 h MVL ED50 thresholds to be 0.35 and 0.55 mu l for the macular and paramacular areas, respectively. The combined data for both areas yielded a threshold of 0.45 mu l. (C) 2000 Society of Photo-Optical Instrumentation Engineers. [S1083-3668(00)00803-0].