Hookworm-provoked IgE-mediated pathology: Capricious damage or remarkable strategy?

被引：6

作者：

Croese, J ^{[1
]}

机构：

[1] Townsville Gen Hosp, Townsville, Qld 4810, Australia

来源：

PARASITOLOGY TODAY | 1998年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0169-4758(97)01166-6

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The existence of the canine hookworm Ancylostoma caninum in the human gut stems to be curtailed by an effective IgE-mediated inflammatory response against the helminth's feeding secretions, which, by damaging the host, compromises the parasite's feeding opportunities. In contrast, immunity does not develop against adapted, anthropophilic hookworm species, and it is suggested this relates to modulation of the inflammatory response by hookworm secretions. Here, John Croese discusses this hypothesis and its implications for the development of drugs to suppress allergy.

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页码：70 / 72

页数：3

相关论文

共 31 条

[1] SEROLOGICAL REACTIONS TO INFECTION WITH NECATOR AMERICANUS [J].

BALL, PAJ ;

BARTLETT, A .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1969, 63 (03) :362-&

[2]

BEHNKE JM, 1990, HOOKWORM DISEASE : CURRENT STATUS AND NEW DIRECTIONS, P105

[3] DO HOOKWORMS ELICIT PROTECTIVE IMMUNITY IN MAN [J].

BEHNKE, JM .

PARASITOLOGY TODAY, 1987, 3 (07) :200-206

[4] ANCYLOSTOMA FACTOR XA INHIBITOR - PARTIAL-PURIFICATION AND ITS IDENTIFICATION AS A MAJOR HOOKWORM-DERIVED ANTICOAGULANT INVITRO [J].

CAPPELLO, M ;

CLYNE, LP ;

MCPHEDRAN, P ;

HOTEZ, PJ .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (06) :1474-1477

[5] ANCYLOSTOMA-CEYLANICUM - IMMUNIZATION WITH SOLUBLE WORM EXTRACT AND RESPONSES TO CHALLENGE INFECTION OF DOGS [J].

CARROLL, SM ;

GROVE, DI .

EXPERIMENTAL PARASITOLOGY, 1985, 60 (03) :263-269

[6]

CARROLL SM, 1984, THROMB HAEMOSTASIS, V51, P222

[7] SEASONAL INFLUENCE ON HUMAN ENTERIC INFECTION BY ANCYLOSTOMA-CANINUM [J].

CROESE, J .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1995, 53 (02) :158-161

[8] HUMAN ENTERIC INFECTION WITH CANINE HOOKWORMS [J].

CROESE, J ;

LOUKAS, A ;

OPDEBEECK, J ;

FAIRLEY, S ;

PROCIV, P .

ANNALS OF INTERNAL MEDICINE, 1994, 120 (05) :369-374

[9] A distinctive aphthous ileitis linked to Ancylostoma caninum [J].

Croese, J ;

Fairley, S ;

Loukas, A ;

Hack, J ;

Stronach, P .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1996, 11 (06) :524-531

[10] OCCULT ENTERIC INFECTION BY ANCYLOSTOMA-CANINUM - A PREVIOUSLY UNRECOGNIZED ZOONOSIS [J].

CROESE, J ;

LOUKAS, A ;

OPDEBEECK, J ;

PROCIV, P .

GASTROENTEROLOGY, 1994, 106 (01) :3-12

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