Antiprotozoal activities of phospholipid analogues

被引：140

作者：

Croft, SL

Seifert, K

Duchêne, M

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] AKH, Div Specif Prophylaxis & Trop Med, Dept Pathophysiol, A-1090 Vienna, Austria

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2003年 / 126卷 / 02期

基金：

奥地利科学基金会;

关键词：

phospholipid analogues; miltefosine; protozoa;

D O I：

10.1016/S0166-6851(02)00283-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antiprotozoal activity of phospholipid analogues, originally developed as anti-cancer drugs, has been determined in the past decade. The most susceptible parasites are Leishmania spp. and Trypanosoma cruzi with activity also shown against Trypanosoma brucei spp., Entamoeba histolytica and Acanthamoeba spp. Miltefosine, an alkylphosphocholine, was registered for the oral treatment of visceral leishmaniasis (VL) in India in March 2002. This review will focus on the biological activities of phospholipid analogues. Biochemical and molecular targets and mechanism(s) of action have been studied extensively in tumor cells but have not been determined in protozoa. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：165 / 172

页数：8

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