Biodegradable polymersomes

被引：194

作者：

Meng, FH ^{[1
]}

Hiemstra, C ^{[1
]}

Engbers, GHM ^{[1
]}

Feijen, J ^{[1
]}

机构：

[1] Univ Twente, Dept Chem Technol, Inst Biomed Technol, Polymer Chem & Biomat Grp, NL-7500 AE Enschede, Netherlands

来源：

MACROMOLECULES | 2003年 / 36卷 / 09期

关键词：

D O I：

10.1021/ma034040+

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Biodegradable polymersomes based on block copolymers of PEG and polyester or polycarbonates were prepared from a variety of organic solvents and water combinations. Biodegradable polymersomes with sizes ranging from 70 nm to 50μm were readily prepared. The subsequent removal of the organic solvents from the polymersomes increased with stability. These biodegradable polymersomes have a high potential for biomedical applications.

引用

页码：3004 / 3006

页数：3

共 13 条

[1]

Chécot F, 2002, ANGEW CHEM INT EDIT, V41, P1339, DOI 10.1002/1521-3773(20020415)41:8<1339::AID-ANIE1339>3.0.CO

[2]

2-N

[3] Helical superstructures from charged poly(styrene)-poly(isocyanodipeptide) block copolymers [J].

Cornelissen, JJLM ;

Fischer, M ;

Sommerdijk, NAJM ;

Nolte, RJM .

SCIENCE, 1998, 280 (5368) :1427-1430

[4] Polyisoprene-block-poly(2-cinnamoylethyl methacrylate) vesicles and their aggregates [J].

Ding, JF ;

Liu, GJ .

MACROMOLECULES, 1997, 30 (03) :655-657

[5] Polymersomes: Tough vesicles made from diblock copolymers [J].

Discher, BM ;

Won, YY ;

Ege, DS ;

Lee, JCM ;

Bates, FS ;

Discher, DE ;

Hammer, DA .

SCIENCE, 1999, 284 (5417) :1143-1146

[6] The first example of a poly(ethylene oxide) poly(methylphenylsilane) amphiphilic block copolymer: vesicle formation in water [J].

Holder, SJ ;

Hiorns, RC ;

Sommerdijk, NAJM ;

Williams, SJ ;

Jones, RG ;

Nolte, RJM .

CHEMICAL COMMUNICATIONS, 1998, (14) :1445-1446

[7] The formation of polymer vesicles or "peptosomes" by polybutadiene-block-poly(L-glutamate)s in dilute aqueous solution [J].

Kukula, H ;

Schlaad, H ;

Antonietti, M ;

Förster, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) :1658-1663

[8] Preparation, stability, and in vitro performance of vesicles made with diblock copolymers [J].

Lee, JCM ;

Bermudez, H ;

Discher, BM ;

Sheehan, MA ;

Won, YY ;

Bates, FS ;

Discher, DE .

BIOTECHNOLOGY AND BIOENGINEERING, 2001, 73 (02) :135-145

[9] Synthetic biodegradable polymers as orthopedic devices [J].

Middleton, JC ;

Tipton, AJ .

BIOMATERIALS, 2000, 21 (23) :2335-2346

[10] Polymerized ABA triblock copolymer vesicles [J].

Nardin, C ;

Hirt, T ;

Leukel, J ;

Meier, W .

LANGMUIR, 2000, 16 (03) :1035-1041

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