Heterogeneity of a Campylobacter jejuni protein that is secreted through the flagellar filament

被引：72

作者：

Poly, Frederic ^{[1
]}

Ewing, Cheryl ^{[1
]}

Goon, Scarlett ^{[1
]}

Hickey, Thomas E. ^{[1
]}

Rockabrand, David ^{[1
]}

Majam, Gary ^{[1
]}

Lee, Lanfong ^{[1
]}

Phan, Julie ^{[1
]}

Savarino, Nicholas J. ^{[1
]}

Guerry, Patricia ^{[1
]}

机构：

[1] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 08期

关键词：

D O I：

10.1128/IAI.00159-07

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a sigma(28) promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.

引用

页码：3859 / 3867

页数：9

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