Autophagy in transition from hypertrophic cardiomyopathy to heart failure

被引：49

作者：

Fidzianska, Anna ^{[2
]}

Bilinska, Zofia T. ^{[1
]}

Walczak, Ewa ^{[3
]}

Witkowski, Adam ^{[4
]}

Chojnowska, Lidia ^{[1
]}

机构：

[1] Inst Cardiol, Dept Coronary Artery Dis 1, Warsaw, Poland

[2] Polish Acad Sci, MRC, Neuromuscular Unit, Warsaw, Poland

[3] Inst Rheumatol, Dept Pathol, Warsaw, Poland

[4] Inst Cardiol, Catheterizat Lab, Warsaw, Poland

来源：

JOURNAL OF ELECTRON MICROSCOPY | 2010年 / 59卷 / 02期

关键词：

hypertrophic cardiomyopathy; heart failure; autophagy; endomyocardial biopsy; pathology; DISEASE;

D O I：

10.1093/jmicro/dfp048

中图分类号：

TH742 [显微镜];

学科分类号：

080401 [精密仪器及机械];

摘要：

Endomyocardial biopsy of a patient in transition stage from hypertrophic cardiomyopathy to heart failure was investigated. The tissue showed hypertrophy, atrophy of myocytes and an increased amount of fibrosis. In addition, numerous cardiomyocytes revealed ubiquitin positive inclusions. Ultrastructural analysis indicated that cardiomyocytes contained typical autophagic vacuoles including mitochondria, glycogen granules, degraded remnants and myelin structures. The most obvious ultrastructural finding was the presence of amorphous plaques and tubulofilamentous inclusions. Such ultrastructural abnormalities allow us to conclude that degeneration of myocardial cells by autophagy mechanisms leads to cardiomyocyte death, loss and heart failure.

引用

页码：181 / 183

页数：3

共 5 条

[1]

Autophagy in Ischemic Heart Disease [J].

Gustafsson, Asa B. ;

Gottlieb, Roberta A. .

CIRCULATION RESEARCH, 2009, 104 (02) :150-158

[2]

Progression from compensated hypertrophy to failure in the pressure-overloaded human heart -: Structural deterioration and compensatory mechanisms [J].

Hein, S ;

Arnon, E ;

Kostin, S ;

Schönburg, M ;

Elsässer, A ;

Polyakova, V ;

Bauer, EP ;

Klövekorn, WP ;

Schaper, J .

CIRCULATION, 2003, 107 (07) :984-991

[3]

The role of autophagy in the heart [J].

Nishida, K. ;

Kyoi, S. ;

Yamaguchi, O. ;

Sadoshima, J. ;

Otsu, K. .

CELL DEATH AND DIFFERENTIATION, 2009, 16 (01) :31-38

[4]

Autophagy in Load-Induced Heart Disease [J].

Rothermel, Beverly A. ;

Hill, Joseph A. .

CIRCULATION RESEARCH, 2008, 103 (12) :1363-1369

[5]

Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy [J].

Shimomura, H ;

Terasaki, F ;

Hayashi, T ;

Kitaura, Y ;

Isomura, T ;

Suma, H .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 2001, 65 (11) :965-968

← 1 →