Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog

被引：46

作者：

Kira, K ^{[1
]}

Isobe, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

ciguatoxin; acetylene cobalt complex; hydrosilylation; vinylsilane;

D O I：

10.1016/S0040-4039(00)00988-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to the (D)EF analog of ciguatoxin has been explored through acetylene cobalt complex and vinylsilane strategy. The central reactions in the synthesis are: (i) ether ring formation mediated by acetylene cobalt complex and (ii) decomplexation of the endo-acetylene cobalt complexes to vinylsilanes or olefins. Unusual rearrangement of epoxy-silane to allylic alcohol is also described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5951 / 5955

页数：5

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