Identification of complexes involving toxic heavy metals with amino acid ligands by electrospray ionization mass spectrometry

被引：28

作者：

Burford, N ^{[1
]}

Eelman, MD ^{[1
]}

LeBlanc, WG ^{[1
]}

机构：

[1] Dalhousie Univ, Dept Chem, Halifax, NS B3H 4J3, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2004年 / 82卷 / 08期

关键词：

heavy metals; amino acids; electrospray ionization mass spectrometry;

D O I：

10.1139/V04-095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Electrospray ionization mass spectra (ESI-MS) of reaction mixtures containing ions of the heavy metals, cadmium, mercury, thallium, lead, and bismuth with each of the naturally occurring amino acids allows for definitive identification of monocationic complexes in the gas phase. Prominent m/z peaks are assigned to ions of the type [E(Am) - xH](+) (x = 0, 1, 2), [E(Am)(2) - xH](+) (x = 0, 1, 2), [E-2(Am) - xH](+) (x = 1, 2, 3), and (or) [E-2(Am)(2) - xH](+) (x = 1, 3, 5) for all amino acids studied (Am) with all metals studied (E = Cd, Hg, Tl, Pb) except bismuth, which shows complexes with only seven amino acids (Am = His, Thr, Met, Cys, Hcys, Asn, Gln). The results demonstrate the potential application of ESI-MS as a versatile and efficient approach to study toxic heavy metals in biological systems.

引用

页码：1254 / 1259

页数：6

共 19 条

[1]

ARENA JM, 1986, POISONING TOXICOLOGY

[2] Evaluation of binding selectivities of caged crown ligands toward heavy metals by electrospray ionization/quadrupole ion trap mass spectrometry [J].

Blair, SM ;

Brodbelt, JS ;

Marchand, AP ;

Kumar, KA ;

Chong, HS .

ANALYTICAL CHEMISTRY, 2000, 72 (11) :2433-2445

[3] Synthesis and structures of the first bismuth-ester complexes using heterobifunctional thiolate anchored ligands and mass spectrometric identification of ligand-bridged derivatives [J].

Briand, GG ;

Burford, N ;

Eelman, MD ;

Cameron, TS ;

Robertson, KN .

INORGANIC CHEMISTRY, 2003, 42 (09) :3136-3141

[4] Bismuth compounds and preparations with biological or medicinal relevance [J].

Briand, GG ;

Burford, N .

CHEMICAL REVIEWS, 1999, 99 (09) :2601-2657

[5] Coordination complexes of bismuth(III) involving organic ligands with pnictogen or chalcogen donors [J].

Briand, GG ;

Burford, N .

ADVANCES IN INORGANIC CHEMISTRY, VOL 50: MAIN GROUP CHEMISTRY, 2000, 50 :285-357

[6] Definitive identification of lead(II)-amino acid adducts and the solid state structure of a lead-valine complex [J].

Burford, N ;

Eelman, MD ;

LeBlanc, WG ;

Cameron, TS ;

Robertson, KN .

CHEMICAL COMMUNICATIONS, 2004, (03) :332-333

[7] Definitive identification of cysteine and glutathione complexes of bismuth by mass spectrometry: assessing the biochemical fate of bismuth pharmaceutical agents [J].

Burford, N ;

Eelman, MD ;

Mahony, DE ;

Morash, M .

CHEMICAL COMMUNICATIONS, 2003, (01) :146-147

[8] Comprehensive characterisation of bismuth thiosalicylate complexes: models for bismuth subsalicylate [J].

Burford, N ;

Eelman, MD ;

Cameron, TS .

CHEMICAL COMMUNICATIONS, 2002, (13) :1402-1403

[9] Trivalent lanthanide interactions with a terdentate bis(dialkyltriazinyl)pyridine ligand studied by electrospray ionization mass spectrometry [J].

Colette, S ;

Amekraz, B ;

Madic, C ;

Berthon, L ;

Cote, G ;

Moulin, C .

INORGANIC CHEMISTRY, 2003, 42 (07) :2215-2226

[10] METHYLMERCURY(II) COMPLEXES WITH TRYPTOPHAN AND ITS N-ACETYL DERIVATIVE [J].

CORBEIL, MC ;

BEAUCHAMP, AL .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1988, 66 (09) :2458-2464

← 1 2 →