Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

被引：340

作者：

Park, Keigan M. ^{[1
,4
]}

Bowers, William J. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Rochester, Ctr Neural Dev & Dis, Med Ctr, Sch Med & Dent, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

[3] Univ Rochester, Med Ctr, Dept Microbiol & Immunol, Rochester, NY 14642 USA

[4] Univ Rochester, Med Ctr, Dept Physiol & Pharmacol, Rochester, NY 14642 USA

来源：

CELLULAR SIGNALLING | 2010年 / 22卷 / 07期

关键词：

TNF-alpha; Neuroinflammation; Alzheimer's; Parkinson's; Synaptic plasticity; Ionic homeostasis; NF-KAPPA-B; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LONG-TERM POTENTIATION; ALZHEIMERS-DISEASE; TNF-ALPHA; PARKINSONS-DISEASE; CELL-DEATH; MICROGLIAL ACTIVATION; TRANSGENIC MICE;

D O I：

10.1016/j.cellsig.2010.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology. (C) 2010 Elsevier Inc. All rights reserved.

引用

收藏

页码：977 / 983

页数：7

相关论文

共 110 条

[1]

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial [J].

Aisen, PS ;

Schafer, KA ;

Grundman, M ;

Pfeiffer, E ;

Sano, M ;

Davis, KL ;

Farlow, MR ;

Jin, S ;

Thomas, RG ;

Thal, LJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2819-2826

[2]

Albensi BC, 2000, SYNAPSE, V35, P151

[3]

Overexpression of tumour necrosis factor α in the brain of transgenic mice differentially alters nerve growth factor levels and choline acetyltransferase activity [J].

Aloe, L ;

Fiore, M ;

Probert, L ;

Turrini, P ;

Tirassa, P .

CYTOKINE, 1999, 11 (01) :45-54

[4]

Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation [J].

Babcock, Alicia A. ;

Wirenfeldt, Martin ;

Holm, Thomas ;

Nielsen, Helle H. ;

Dissing-Olesen, Lasse ;

Toft-Hansen, Henrik ;

Millward, Jason M. ;

Landmann, Regine ;

Rivest, Serge ;

Finsen, Bente ;

Owens, Trevor .

JOURNAL OF NEUROSCIENCE, 2006, 26 (49) :12826-12837

[5]

Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells [J].

Badiola, Nahuai ;

Malagelada, Cristina ;

Llecha, Nuria ;

Hidalgo, Juan ;

Comella, Joan X. ;

Sabria, Josefa ;

Rodriguez-Alvarez, Jose .

NEUROBIOLOGY OF DISEASE, 2009, 35 (03) :438-447

[6]

Modulation of life and death by the TNF receptor superfamily [J].

Baker, SJ ;

Reddy, EP .

ONCOGENE, 1998, 17 (25) :3261-3270

[7]

TUMOR-NECROSIS-FACTOR-ALPHA AND TUMOR-NECROSIS-FACTOR-BETA PROTECT NEURONS AGAINST AMYLOID BETA-PEPTIDE TOXICITY - EVIDENCE FOR INVOLVEMENT OF A KAPPA-B-BINDING FACTOR AND ATTENUATION OF PEROXIDE AND CA2+ ACCUMULATION [J].

BARGER, SW ;

HORSTER, D ;

FURUKAWA, K ;

GOODMAN, Y ;

KRIEGLSTEIN, J ;

MATTSON, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9328-9332

[8]

Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus [J].

Barrat, FJ ;

Meeker, T ;

Gregorio, J ;

Chan, JH ;

Uematsu, S ;

Akira, S ;

Chang, B ;

Duramad, O ;

Coffman, RL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1131-1139

[9]

Control of synaptic strength by glial TNFα [J].

Beattie, EC ;

Stellwagen, D ;

Morishita, W ;

Bresnahan, JC ;

Ha, BK ;

Von Zastrow, M ;

Beattie, MS ;

Malenka, RC .

SCIENCE, 2002, 295 (5563) :2282-2285

[10]

INCREASED PRODUCTION OF INTERFERON GAMMA AND TUMOR NECROSIS FACTOR PRECEDES CLINICAL MANIFESTATION IN MULTIPLE-SCLEROSIS - DO CYTOKINES TRIGGER OFF EXACERBATIONS [J].

BECK, J ;

RONDOT, P ;

CATINOT, L ;

FALCOFF, E ;

KIRCHNER, H ;

WIETZERBIN, J .

ACTA NEUROLOGICA SCANDINAVICA, 1988, 78 (04) :318-323

← 1 2 3 4 5 6 7 8 9 10 →