The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

被引：127

作者：

Balagopalan, Lakshmi ^{[1
]}

Coussens, Nathan P. ^{[1
]}

Sherman, Eilon ^{[1
]}

Samelson, Lawrence E.

Sommers, Connie L.

机构：

[1] NCI, LCMB, CCR, NIH, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 08期

关键词：

T-CELL-RECEPTOR; C-CBL PROTOONCOGENE; PHOSPHOLIPASE C-GAMMA-1 PLC-GAMMA-1; PLASMA-MEMBRANE MICRODOMAINS; MEDIATED SIGNALING PATHWAYS; HOMOLOGY; DOMAIN; FC-EPSILON-RI; ANTIGEN RECEPTOR; ADAPTER PROTEIN; LIPID RAFTS;

D O I：

10.1101/cshperspect.a005512

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.

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页数：20

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