What's good for the host is good for the bug

被引：105

作者：

Flynn, JL ^{[1
]}

Chan, J

机构：

[1] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

[2] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

TRENDS IN MICROBIOLOGY | 2005年 / 13卷 / 03期

关键词：

D O I：

10.1016/j.tim.2005.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tuberculosis, caused by Mycobacterium tuberculosis, kills approximately two million people each year. The infection is characterized by an inflammatory response culminating in the formation of a granuloma, a collection of immune cells that controls the infection. However, the granuloma can be the source of immunopathology that encourages transmission. Recent data support the idea that mycobacterial products can positively and negatively regulate the inflammatory response. Our contention is that induction of the immune response and subsequent granuloma formation is beneficial to the host for control of infection, and is also beneficial to the bacillus, as a place to hide and as a means for transmitting the infection to naive hosts.

引用

页码：98 / 102

页数：5

共 42 条

[1] Influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during mycobacterium tuberculosis infection [J].

Algood, HMS ;

Lin, PL ;

Yankura, D ;

Jones, A ;

Chan, J ;

Flynn, JL .

JOURNAL OF IMMUNOLOGY, 2004, 172 (11) :6846-6857

[2] Chemokines and tuberculosis [J].

Algood, HMS ;

Chan, J ;

Flynn, JL .

CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (06) :467-477

[3] Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls [J].

Apostolou, I ;

Takahama, Y ;

Belmant, C ;

Kawano, T ;

Huerre, M ;

Marchal, G ;

Cui, J ;

Taniguchi, M ;

Nakauchi, H ;

Fournié, JJ ;

Kourilsky, P ;

Gachelin, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (09) :5141-5146

[4]

Bean AGD, 1999, J IMMUNOL, V162, P3504

[5] Trafficking and release of mycobacterial lipids from infected macrophages [J].

Beatty, WL ;

Rhoades, ER ;

Ullrich, HJ ;

Chatterjee, D ;

Heuser, JE ;

Russell, DG .

TRAFFIC, 2000, 1 (03) :235-247

[6]

BEHLING CA, 1993, ANN CLIN LAB SCI, V23, P256

[7] Fate of Mycobacterium tuberculosis within murine dendritic cells [J].

Bodnar, KA ;

Serbina, NV ;

Flynn, JL .

INFECTION AND IMMUNITY, 2001, 69 (02) :800-809

[8] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[9] Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response [J].

Briken, V ;

Porcelli, SA ;

Besra, GS ;

Kremer, L .

MOLECULAR MICROBIOLOGY, 2004, 53 (02) :391-403

[10] The use of maximum likelihood methods to estimate the risk of tuberculous infection and disease in a Canadian First Nations population [J].

Clark, M ;

Vynnycky, E .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (03) :477-484

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