RETRACTED: The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis (Retracted Article)

被引：57

作者：

Bie, Yaqin ^{[1
,2
,3
]}

Ge, Wei ^{[2
]}

Yang, Zhibin ^{[1
]}

Cheng, Xianshuo ^{[1
]}

Zhao, Zefeng ^{[1
]}

Li, Shengjie ^{[1
]}

Wang, Wenchao ^{[3
]}

Wang, Yu ^{[3
]}

Zhao, Xiaofeng ^{[1
]}

Yin, Zhengfeng ^{[3
]}

Li, Yunfeng ^{[1
]}

机构：

[1] Kunming Med Univ, Tumor Hosp Yunnan Prov, Colorectal Surg, Affiliated Hosp 3, Kunming 650118, Yunnan, Peoples R China

[2] Taikang Tongji Wuhan Hosp, Oncol, Wuhan 430051, Hubei, Peoples R China

[3] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Mol Oncol Lab, Shanghai 200438, Peoples R China

来源：

DISEASE MARKERS | 2019年 / 2019卷

基金：

中国国家自然科学基金;

关键词：

DUFFY ANTIGEN RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; MEDIATED INTERLEUKIN-8 PRODUCTION; COLON-CANCER; ENDOTHELIAL-CELLS; SUPPRESSOR-CELLS; CARCINOMA CELLS; BREAST-CANCER; TUMOR; EXPRESSION;

D O I：

10.1155/2019/8023460

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

CXCL8 (also known as IL-8) can produce different biological effects by binding to its receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 and its receptors are associated with the development of various tumor types, especially colorectal cancer and its liver metastases. In addition to promoting angiogenesis, proliferation, invasion, migration, and the survival of colorectal cancer (CRC) cells, CXCL8 and its receptors have also been known to induce the epithelial-mesenchymal transition (EMT) of CRC cells, to help them to escape host immunosurveillance as well as to enhance resistance to anoikis, which promotes the formation of circulating tumor cells (CTCs) and their colonization of distant organs. In this paper, we will review the established roles of CXCL8 signaling in CRC and discuss the possible strategies of targeting CXCL8 signaling for overcoming CRC drug resistance and cancer progression, including direct targeting of CXCL8/CXCR1/2 or indirect targeting through the inhibition of CXCL8-CXCR1/2 signaling.

引用

页数：12

共 74 条

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