Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal Streptococcus and Actinomyces species

被引：23

作者：

Li, T

Bratt, P

Jonsson, AP

Ryberg, M

Johansson, I

Griffiths, WJ

Bergman, T

Strömberg, N ^{[1
]}

机构：

[1] Umea Univ, Dept Cariol, SE-90187 Umea, Sweden

[2] Karolinska Inst, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 09期

关键词：

D O I：

10.1128/IAI.68.9.5425-5429.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr(1)-Pro(104)Pro(105) and a Gly(111)-Pro(149)Gln(150) peptide together with a presumed Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) pentapeptide. The synthetic Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.

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收藏

页码：5425 / 5429

页数：5

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