Neither glutamine nor arginine supplementation of diets increase glutamine body stores in healthy growing rats

被引:12
作者
Boza, JJ [1 ]
Moënnoz, D [1 ]
Jarret, AR [1 ]
Vuichoud, J [1 ]
Garcìa-Ròdenas, C [1 ]
Finot, PA [1 ]
Ballèvre, O [1 ]
机构
[1] Nestec Ltd, Nestle Res Ctr, CH-1000 Lausanne 26, Switzerland
关键词
glutamine; arginine; enteral nutrition; de novo synthesis of glutamine; whey proteins; rats;
D O I
10.1054/clnu.2000.0115
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The aim of the work was to resolve whether glutamine and arginine supplemented diets affect plasma and tissue (muscle, liver and intestinal mucosa) glutamine concentrations, as well as glutaminase and glutamine synthetase specific activities. The trial was performed in growing rats fed 10% protein diets for 3 weeks. Protein sources were: whey proteins (W); whey proteins + free glutamine (WG); whey proteins + arginine (WA); and casein + wheat protein hydrolysate + acid whey (39:39:22), as source containing protein-bound glutamine (CGW). Rats fed the control diet (6.4% glutamine) (W) showed comparable glutamine body stores to those of rats fed the WG diet. In fact, glutamine supplementation down-regulated the hepatic glutamine synthetic capacity of growing rats (W/WG: 6.8 +/- 0.3 vs 6.0 +/- 0.2 nmol/min/mg protein). Arginine supplementation of the diet (up to 9% of the protein content) resulted in a decrease in plasma and tissue glutamine concentrations (W/WA. plasma, 1218 +/- 51 vs 1031 +/- 48 mu mol/L; liver 7.5 +/- 0.4 vs 6.5 +/- 0.2 mu mol/g; muscle: 5.7 +/- 0.2 vs 4.0 +/- 0.2 mu mol/g). These data suggest that glutamine supplementation of the diet does not increase plasma and tissue glutamine concentrations in healthy growing rats, while the addition of arginine to the diet decreases glutamine body stores. (C) 2000 Harcourt Publishers Ltd.
引用
收藏
页码:319 / 325
页数:7
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