Multiple paths towards repair in multiple sclerosis

被引:7
作者
Colman, D
Lubetzki, C
Reingold, S
机构
[1] Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
[2] Hop La Pitie Salpetriere, F-75043 Paris 13, France
[3] Natl Multiple Sclerosis Soc, New York, NY 10017 USA
关键词
D O I
10.1016/S0166-2236(02)00015-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS, affecting similar to 1 /1000 individuals in the Western world. Available treatments limit CNS inflammation and, strategies to repair damage in the CNS offer the potential of recovery of both tissue and function. With further fundamental knowledge developing, this area is ripe for 'translation' to clinical application.
引用
收藏
页码:59 / 61
页数:3
相关论文
共 19 条
[1]   Modelling large areas of demyelination in the rat reveals the potential and possible limitations of transplanted glial cells for remyelination in the CNS [J].
Blakemore, WF ;
Chari, DM ;
Gilson, JM ;
Crang, AJ .
GLIA, 2002, 38 (02) :155-168
[2]   Haematopoietic progenitor cells from adult bone marrow differentiate into cells that express oligodendroglial antigens in the neonatal mouse brain [J].
Bonilla, S ;
Alarcón, P ;
Villaverde, R ;
Aparicio, P ;
Silva, A ;
Martínez, S .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (03) :575-582
[3]   Arginase I and Polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro [J].
Cai, DM ;
Deng, KW ;
Mellado, W ;
Lee, J ;
Ratan, RR ;
Filbin, MT .
NEURON, 2002, 35 (04) :711-719
[4]   Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis? [J].
Charles, P ;
Reynolds, R ;
Seilhean, D ;
Rougon, G ;
Aigrot, MS ;
Niezgoda, A ;
Zalc, B ;
Lubetzki, C .
BRAIN, 2002, 125 :1972-1979
[5]   CAMs and axonal growth: A critical evaluation of the role of calcium and the MAPK cascade [J].
Doherty, P ;
Williams, G ;
Williams, EJ .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (04) :283-295
[6]   Schwann cell transplantation and myelin repair of the CNS [J].
Evercooren, ABV ;
AvellanaAdalid, V ;
Lachapelle, F ;
Liblau, R .
MULTIPLE SCLEROSIS JOURNAL, 1997, 3 (02) :157-161
[7]   Longitudinal brain volume measurement in multiple sclerosis - Rate of brain atrophy is independent of the disease subtype [J].
Kalkers, NF ;
Ameziane, N ;
Bot, JCJ ;
Minneboo, A ;
Polman, CH ;
Barkhof, F .
ARCHIVES OF NEUROLOGY, 2002, 59 (10) :1572-1576
[8]  
Lakatos A, 2000, GLIA, V32, P214, DOI 10.1002/1098-1136(200012)32:3<214::AID-GLIA20>3.0.CO
[9]  
2-7
[10]   Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance [J].
Miller, David H. ;
Barkhof, Frederik ;
Frank, Joseph A. ;
Parker, Geoffrey J. M. ;
Thompson, Alan J. .
BRAIN, 2002, 125 :1676-1695