The promise of gene therapy in gastrointestinal and liver diseases

被引:26
作者
Prieto, J [1 ]
Herraiz, M [1 ]
Sangro, B [1 ]
Qian, C [1 ]
Mazzolini, G [1 ]
Melero, I [1 ]
Ruiz, J [1 ]
机构
[1] Univ Navarra, Clin Univ, Dept Med, Div Hepatol & Gene Therapy, E-31080 Pamplona, Spain
关键词
D O I
10.1136/gut.52.suppl_2.ii49
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gene therapy consists of the transfer of genetic material to cells to achieve a therapeutic goal. In the field of gastroenterology and hepatology gene therapy has produced considerable expectation as a potential tool in the management of conditions that lack effective therapy including non-resectable neoplasms of the liver, pancreas and gastrointestinal tract, chronic viral hepatitis unresponsive to interferon therapy, liver cirrhosis, and inflammatory bowel disease.
引用
收藏
页码:II49 / II54
页数:6
相关论文
共 60 条
[1]  
ALT M, 1995, HEPATOLOGY, V22, P707
[2]  
Amiss TJ, 2001, METH MOL B, V175, P455
[3]   HERPESVIRUS-MEDIATED GENE DELIVERY INTO THE RAT-BRAIN - SPECIFICITY AND EFFICIENCY OF THE NEURON-SPECIFIC ENOLASE PROMOTER [J].
ANDERSEN, JK ;
FRIM, DM ;
ISACSON, O ;
BREAKEFIELD, XO .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 1993, 13 (05) :503-515
[4]   Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis [J].
Aurisicchio, L ;
Delmastro, P ;
Salucci, V ;
Paz, OG ;
Rovere, P ;
Ciliberto, G ;
La Monica, N ;
Palombo, F .
JOURNAL OF VIROLOGY, 2000, 74 (10) :4816-4823
[5]   Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12 [J].
Barajas, M ;
Mazzolini, G ;
Genové, G ;
Bilbao, R ;
Narvaiza, I ;
Schmitz, V ;
Sangro, B ;
Melero, I ;
Qian, C ;
Prieto, J .
HEPATOLOGY, 2001, 33 (01) :52-61
[6]   PACKAGING CAPACITY AND STABILITY OF HUMAN ADENOVIRUS TYPE-5 VECTORS [J].
BETT, AJ ;
PREVEC, L ;
GRAHAM, FL .
JOURNAL OF VIROLOGY, 1993, 67 (10) :5911-5921
[7]   GENE-THERAPY - A NOVEL FORM OF DRUG-DELIVERY [J].
BLAU, HM ;
SPRINGER, ML .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (18) :1204-1207
[8]   INHIBITION OF HEPATITIS-B VIRUS BY ANTISENSE OLIGODEOXYNUCLEOTIDES [J].
BLUM, HE ;
GALUN, E ;
VONWEIZSACKER, F ;
WANDS, JR .
LANCET, 1991, 337 (8751) :1230-1230
[9]   Baculovirus-mediated gene transfer into mammalian cells [J].
Boyce, FM ;
Bucher, NLR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (06) :2348-2352
[10]   Adeno associated viral vectors for gene transfer and gene therapy [J].
Büeler, H .
BIOLOGICAL CHEMISTRY, 1999, 380 (06) :613-622