Microfabricated devices for sizing DNA and sorting cells

被引：6

作者：

Chou, HP ^{[1
]}

Spence, C ^{[1
]}

Scherer, A ^{[1
]}

Quake, S ^{[1
]}

机构：

[1] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA

来源：

MICRO- AND NANOFABRICATED STRUCTURES AND DEVICES FOR BIOMEDICAL ENVIRONMENTAL APPLICATIONS | 1998年 / 3258卷

关键词：

MEMS; cell sorting; DNA diagnostics;

D O I：

10.1117/12.304378

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We have microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA. Sizing is accomplished by fluorescent excitation and detection. The devices are fabricated in a silicone elastomer using a replica method. Single molecules of DNA have been sized to 10% accuracy, and manipulation of E. Coli cells has been demonstrated.

引用

页码：181 / 187

页数：7