Magnetic resonance and light microscopy investigation of a dextran coated magnetic fluid

被引：19

作者：

Lacava, LM

Garcia, VAP

Kückelhaus, S

Azevedo, RB

Lacava, ZGM ^{[1
]}

Silva, O

Pelegrini, F

Gansau, C

Buske, N

Morais, PC

机构：

[1] Univ Brasilia, Inst Ciencias Biol, BR-70910900 Brasilia, DF, Brazil

[2] Univ Fed Goias, Inst Fis, BR-74001970 Goiania, Go, Brazil

[3] Berlin Heart AG, D-12247 Berlin, Germany

[4] Univ Brasilia, Inst Fis, BR-70919970 Brasilia, DF, Brazil

来源：

JOURNAL OF APPLIED PHYSICS | 2003年 / 93卷 / 10期

关键词：

D O I：

10.1063/1.1540178

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

A dextran-coated magnetite-based magnetic fluid (MF) sample (DexMF) was developed for cancer diagnostic and therapeutic purposes. In order to perform biological studies DexMF samples were endovenously injected into female Swiss mice. Magnetic resonance (MR) spectra showed a broad line around g=2, typical of magnetic nanoparticles (MNPs) suspended in a nonmagnetic matrix. The MR data showed that MNPs essentially spread in liver, spleen, and bone marrow. MNPs in blood stream were found up to 60 min after injection. Histological analysis also showed MNP agglomeration in liver, spleen, and bone marrow, from 1 h up to 28 days. No damaged cells or any other kind of alteration were observed in the investigated tissues. The data suggested that DexMF sample is biocompatible and adequate for biomedical applications. (C) 2003 American Institute of Physics.

引用

页码：7563 / 7565

页数：3

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