Iron metabolism: Iron deficiency and iron overload

被引：160

作者：

Andrews, NC ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Pediat, Boston, MA 02115 USA

[2] Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS | 2000年 / 1卷

关键词：

transferrin; hemochromatosis; divalent metal transporter 1; anemia; ferritin;

D O I：

10.1146/annurev.genom.1.1.75

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Iron is an essential cofactor in a variety of cellular processes. Except for a few unusual bacterial species, iron is indispensable for living organisms. However, free iron is toxic because of its propensity to induce the formation of dangerous free radicals. Consequently, iron balance is tightly regulated. Disorders of iron homeostasis are among the most common afflictions of humans. This review discusses inherited iron deficiency and iron overload disorders and recent insights into their pathophysiology.

引用

页码：75 / 98

页数：26

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