Nucleus-specific alteration of raphe neurons in human neurodegenerative disorders

被引：64

作者：

Kovacs, GG

Klöppel, S

Fischer, I

Dorner, S

Lindeck-Pozza, E

Birner, P

Bötefür, IC

Pilz, P

Volk, B

Budka, H

机构：

[1] Univ Vienna, Inst Neurol, A-1097 Vienna, Austria

[2] Univ Vienna, Clin Inst Pathol, A-1097 Vienna, Austria

[3] Univ Freiburg, Inst Neuropathol, D-7800 Freiburg, Germany

[4] Lanesnervenklin Salzburg, Dept Neurol, Neuropathol Lab, Salzburg, Austria

来源：

NEUROREPORT | 2003年 / 14卷 / 01期

关键词：

Alzheimer's disease; multiple system atrophy; Parkinson's disease; progressive supranuclear palsy; serotonin;

D O I：

10.1097/00001756-200301200-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodegenerative diseases share symptoms suggested to be related to the serotonergic system. To evaluate the involvement of serotonergic raphe nuclei, we compared the percentage of neurons synthesizing serotonin in the nucleus centralis superior (NCS), raphe obscurus and pallidus (NROP) in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), Parkinson's disease (PD), multiple system atrophy (MSA), and control brains. We used immunohistochemistry for tryptophan hydroxylase (TpOH), phosphorylated tau, and alpha-synuclein. We observed a significant decrease in the NCS in the NROP in AD, but a significant increase in PSP and IMSA. Cytoskeletal pathology was present in the NCS and NROP to a variable degree. We conclude that there is disease- and nucleus-specific alteration of serotonin synthesis in the raphe.

引用

页码：73 / 76

页数：4

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