Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis

被引:77
作者
Aktas, Orhan [1 ]
Kieseier, Bernd [1 ]
Hartung, Hans-Peter [1 ]
机构
[1] Univ Dusseldorf, Dept Neurol, D-40225 Dusseldorf, Germany
关键词
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PLACEBO-CONTROLLED MULTICENTER; ORAL FINGOLIMOD FTY720; CONTROLLED PHASE IIB; CD8(+) T-CELLS; AXONAL DAMAGE; DOUBLE-BLIND; MONOCLONAL-ANTIBODY;
D O I
10.1016/j.tins.2009.12.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic inflammatory demyelination and neurodegeneration in the central nervous system. Although the primary cause of this often devastating disease remains elusive, major therapeutic advances have occurred during the past two decades. Here, we present a review of current immunomodulatory treatments and outline upcoming therapy approaches, including biologics and oral alternatives that might have equivalent or superior efficacy and/or enhanced tolerability compared with available treatments, and discuss the scientific rationale and expected benefits and risks for these compounds. We also speculate about alternatives beyond immune-directed approaches, review novel insights into the neurobiological consequences of sustained brain inflammation and evaluate future perspectives for neuroprotective and neuroregenerative treatment strategies for MS.
引用
收藏
页码:140 / 152
页数:13
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