Gray matter volume differences specific to formal thought disorder in schizophrenia

被引：51

作者：

Horn, Helge ^{[1
]}

Federspiel, Andrea ^{[1
]}

Wirth, Miranka ^{[1
]}

Mueller, Thomas J. ^{[1
]}

Wiest, Roland ^{[2
]}

Walther, Sebastian ^{[1
]}

Strik, Werner ^{[1
]}

机构：

[1] Univ Bern, Univ Hosp Psychiat, CH-3010 Bern, Switzerland

[2] Univ Bern, Inst Diagnost & Intervent Neuroradiol, CH-3010 Bern, Switzerland

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2010年 / 182卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

Voxel-based morphometry; Psychopathology; Language; Self-inside; semantic processing; Lexical processing; Schizophrenia; PLANUM TEMPORALE ASYMMETRY; ORBITOFRONTAL CORTEX; AUDITORY HALLUCINATIONS; ILLNESS DURATION; BRAIN VOLUME; LANGUAGE; REVERSAL; GYRUS;

D O I：

10.1016/j.pscychresns.2010.01.016

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Formal thought disorder (FTD) is one of the main symptoms of schizophrenia. To date there are no whole brain volumetric studies investigating gray matter (GM) differences specifically associated with FTD Here, we studied 20 right-handed schizophrenia patients that differed in the seventy of formal thought disorder and 20 matched healthy controls, using voxel-based morphometry (VBM). The seventy of FTD was measured with the Scale for the Assessment of Thought, Language, and Communication. The severity was negatively correlated with the GM volume of the left superior temporal sulcus. the left temporal pole, the right middle orbital gyrus and the right cuneus/lingual gyrus. Structural abnormalities specific for FTD were found to be unrelated to GM differences associated with schizophrenia in general The specific GM abnormalities within the left temporal lobe may help to explain language disturbances included in FTD (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：183 / 186

页数：4

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