A comparison of FibroMeter™ NAFLD Score, NAFLD fibrosis score, and transient elastography as noninvasive diagnostic tools for hepatic fibrosis in patients with biopsy-proven non-alcoholic fatty liver disease

被引:49
作者
Aykut, Umut Emre [1 ]
Akyuz, Umit [2 ]
Yesil, Atakan [3 ]
Eren, Fatih [4 ]
Gerin, Fatma [5 ]
Ergelen, Rabia [6 ]
Celikel, Cigdem Ataizi [5 ]
Yilmaz, Yusuf [4 ,7 ]
机构
[1] Marmara Univ, Sch Med, Dept Internal Med, Istanbul, Turkey
[2] Yeditepe Univ, Fac Med, Dept Gastroenterol, Istanbul, Turkey
[3] Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey
[4] Marmara Univ, Inst Gastroenterol, Istanbul, Turkey
[5] Marmara Univ, Sch Med, Dept Pathol, Istanbul, Turkey
[6] Marmara Univ, Sch Med, Dept Radiol, Istanbul, Turkey
[7] Marmara Univ, Sch Med, Dept Gastroenterol, Istanbul, Turkey
关键词
FibroMeter (TM) NAFLD score; Fibroscan; fibrosis; NAFLD fibrosis score; non-alcoholic fatty liver disease; transient elastography; CONTROLLED ATTENUATION PARAMETER; NATURAL-HISTORY; STEATOHEPATITIS; CIRRHOSIS; EPIDEMIOLOGY; SYSTEM;
D O I
10.3109/00365521.2014.958099
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Background: Noninvasive markers that purport to distinguish patients with non-alcoholic fatty liver disease (NAFLD) with fibrosis from those without must be evaluated rigorously for their classification accuracy. Herein, we seek to compare the diagnostic performances of three different noninvasive methods (FibroMeter (TM) NAFLD score, NAFLD Fibrosis score (NFSA), and Transient Elastrography [TE]) for the detection of liver fibrosis in NAFLD patients. Methods: A total of 88 patients with biopsy-proven NAFLD were included. The Kleiner system was used for grading fibrosis in liver biopsies. The FibroMeter (TM) NAFLD score was determined using a proprietary algorithm (regression score). The NFSA score was calculated based on age, hyperglycemia, body mass index, platelets, albumin and serum aminotransferase levels. TE was performed using the Fibroscan apparatus. Results: The sensitivities/specificities for the FibroMeter (TM) NAFLD score, NFSA, and TE for the diagnosis of significant fibrosis (F2 + F3 + F4 fibrosis) were 38.6%/86.4%, 52.3%/88.6%, and 75.0%/93.2%, respectively. The areas under the receiver operating characteristic curves of TE were significantly higher than those of both the FibroMeter (TM) NAFLD score and NFSA. No significant differences were found between the FibroMeter (TM) NAFLD score and NFSA for the detection of significant and severe fibrosis, although the diagnostic performance of the FibroMeter (TM) NAFLD score was higher than that of the NFSA score for cirrhosis. Conclusions: In summary, TE showed the best diagnostic performance for the noninvasive assessment of liver fibrosis in NAFLD patients. The diagnostic performances of the FibroMeter (TM) NAFLD score and NFSA did not differ significantly for the detection of both significant and severe fibrosis.
引用
收藏
页码:1343 / 1348
页数:6
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