Biosynthesis of vitamin B6 in yeast.: Incorporation pattern of trioses

被引：19

作者：

Zeidler, J ^{[1
]}

Gupta, RN ^{[1
]}

Sayer, BG ^{[1
]}

Spenser, ID ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 09期

关键词：

D O I：

10.1021/jo020730k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biosynthetic origin of the C-3 unit, C-6,5,5', of pyridoxamine was investigated in two yeasts, Candida utilis ATCC 9256 and Saccharomyces cerevisiae ATCC 7752. The incorporation patterns within pyridoxamine bishydrochloride derived from variously multiply C-13- and H-2-labeled samples of glycerol and glyceraldehyde, established by NMR spectroscopy, indicate that the three-carbon unit C-6,5,5' of pyridoxamine is derived intact from a triose.

引用

页码：3486 / 3493

页数：8

共 26 条

[1] Biosynthesis of vitamin B6:: The oxidation of 4-(phosphohydroxy)-L-threonine by PdxA
Cane, DE
Hsiung, YJ
Cornish, JA
Robinson, JK
Spenser, ID
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (08) : 1936 - 1937
[2] Biosynthesis of vitamin B6:: Enzymatic conversion of 1-deoxy-D-xylulose-5-phosphate to pyridoxol phosphate
Cane, DE
Du, SC
Robinson, JK
Hsiung, Y
Spenser, ID
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (33) : 7722 - 7723
[3] Biosynthesis of vitamin B6:: Origin of the oxygen atoms of pyridoxol phosphate
Cane, DE
Du, SC
Spenser, ID
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (17) : 4213 - 4214
[4] A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis
Ehrenshaft, M
Bilski, P
Li, MY
Chignell, CF
Daub, ME
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9374 - 9378
[5] GLYCEROL METABOLISM IN YEASTS - PATHWAYS OF UTILIZATION AND PRODUCTION
GANCEDO, C
GANCEDO, JM
SOLS, A
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1968, 5 (02): : 165 - &
[6] Biosynthesis of vitamin B6 in yeast:: Incorporation pattern of glucose
Gupta, RN
Hemscheidt, T
Sayer, BG
Spenser, ID
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (46) : 11353 - 11359
[7] The biogenetic anatomy of vitamin B-6 - A C-13 NMR investigation of the biosynthesis of pyridoxol in Escherichia coli
Hill, RE
Himmeldirk, K
Kennedy, IA
Pauloski, RM
Sayer, BG
Wolf, E
Spenser, ID
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (48) : 30426 - 30435
[8] HILL RE, 1987, J BIOL CHEM, V262, P7463
[9] Comparative biogenetic anatomy of vitamin B1:: A 13C NMR investigation of the biosynthesis of thiamin in Escherichia coli and in Saccharomyces cerevisiae
Himmeldirk, K
Sayer, BG
Spenser, ID
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (15) : 3581 - 3589
[10] ROLE OF MONO-VALENT AND DIVALENT METAL-CATIONS IN THE CATALYSIS BY YEAST ALDOLASE
KADONAGA, JT
KNOWLES, JR
[J]. BIOCHEMISTRY, 1983, 22 (01) : 130 - 136

← 1 2 3 →