Studies of zoanthamine alkaloids. Enantiocontrolled construction of the tetracyclic hemi-aminal core.

被引:45
作者
Williams, DR [1 ]
Cortez, GS [1 ]
机构
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0040-4039(98)00369-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A concise enantiocontrolled synthesis of the enamine-aminal heterocyclic core found in the zoanthamine alkaloids is presented. Conjugate addition of a chiral imine provides for excellent diastereofacial selectivity in the generation of the quaternary C-9 asymmetry, of 4. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:2675 / 2678
页数:4
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