Selective polymorph transformation via solvent-drop grinding

被引:172
作者
Trask, AV
Shan, N
Motherwell, WDS
Jones, W
Feng, SH
Tan, RBH
Carpenter, KJ
机构
[1] Univ Cambridge, Dept Chem, Pfizer Inst Pharmaceut Mat Sci, Cambridge CB2 1EW, England
[2] Inst Chem & Engn Sci, Singapore 627833, Singapore
[3] Cambridge Crystallog Data Ctr, Cambridge CB2 1EZ, England
关键词
D O I
10.1039/b416980h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A method of inducing specific polymorph transformations is exemplified with two single-component systems, whereby a given crystal form undergoes conversion when subjected to solid state grinding in the presence of a minor quantity of a certain solvent.
引用
收藏
页码:880 / 882
页数:3
相关论文
共 19 条
[1]  
BERNSTEIN J, 2002, POLYMORPHISM MOL CRY, P410
[2]  
BYRN SR, 1999, SOLID STATE CHEM DRU, P261
[3]   Structural characterization, physicochemical properties, and thermal stability of three crystal forms of nifedipine [J].
Caira, MR ;
Robbertse, Y ;
Bergh, JJ ;
Song, MN ;
De Villiers, MM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (12) :2519-2533
[4]   DIRECTING POLYMORPH SELECTIVITY DURING NUCLEATION OF ANTHRANILIC ACID ON MOLECULAR SUBSTRATES [J].
CARTER, PW ;
WARD, MD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (02) :769-770
[5]  
CHAN HK, 1985, DRUG DEV IND PHARM, V11, P315, DOI 10.3109/03639048509056874
[6]   Cryogenic grinding of indomethacin polymorphs and solvates: Assessment of amorphous phase formation and amorphous phase physical stability [J].
Crowley, KJ ;
Zografi, G .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (02) :492-507
[7]   Crystal structures of drugs: Advances in determination, prediction and engineering [J].
Datta, S ;
Grant, DJW .
NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (01) :42-57
[8]   HABIT MODIFICATION OF SUCCINIC ACID CRYSTALS GROWN FROM DIFFERENT SOLVENTS [J].
DAVEY, RJ ;
MULLIN, JW ;
WHITING, MJL .
JOURNAL OF CRYSTAL GROWTH, 1982, 58 (02) :304-312
[9]   HYDROGEN-BOND DIRECTED COCRYSTALLIZATION AND MOLECULAR RECOGNITION PROPERTIES OF ACYCLIC IMIDES [J].
ETTER, MC ;
REUTZEL, SM .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (07) :2586-2598
[10]   Polymorph selectivity under nanoscopic confinement [J].
Ha, JM ;
Wolf, JH ;
Hillmyer, MA ;
Ward, MD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (11) :3382-3383