Multi-functional nanoparticles for cancer therapy

Many immunotherapeutic strategies developed in recent years involve the targeting of immune cells to tumors. In this study, we synthesized and characterized modified fluorescent nanoparticles as a targeting and delivery system, by conjugating both tumor targeting agent and chemokines to the nanoparticles, to attract immune cells to tumor cells. Biodegradable chitosan nanoparticles encapsulating quantum dots were prepared, with suitable surface modification to immobilize both tumor targeting agent and chemokine on their surfaces. The interactions between immune cells and tumor cells were visualized using optical microscope. (c) 2006 NIMS and Elsevier Ltd. All rights reserved.