Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

被引：16

作者：

Gilmore, JH ^{[1
]}

Jarskog, LF

Lindgren, JC

McEvoy, JP

Xiao, H

机构：

[1] Univ N Carolina, Sch Med, Dept Psychiat, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Sch Med, Ctr Neurosci, Chapel Hill, NC 27599 USA

[3] John Umstead Hosp, Butner, NC USA

来源：

PSYCHIATRY RESEARCH | 1997年 / 73卷 / 1-2期

关键词：

hydrocephalus; meningitis; CNS infection; neurotrophic factors;

D O I：

10.1016/S0165-1781(97)00116-9

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme-linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：109 / 113

页数：5

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