phospholipase C gamma-1 is require downstream of vascular endothelial growth factor during arterial development

被引：179

作者：

Lawson, ND ^{[1
]}

Mugford, JW

Diamond, BA

Weinstein, BM

机构：

[1] Univ Massachusetts, Sch Med, Program Gene Funct & Express, Worcester, MA 01605 USA

[2] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 11期

关键词：

zebrafish; endothelial; artery; Plcg1; Vegf;

D O I：

10.1101/gad.1072203

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

In this study, we utilize transgenic zebrafish with fluorescently labeled blood vessels to identify and characterize a mutant (y10) that displays specific defects in the formation of arteries, but not veins. We find that y10 encodes phospholipase C gamma-1 (plcg1), a known effector of receptor tyrosine kinase signaling. We further show that plcg1(y10) mutant embryos fail to respond to exogenous Vegf. Our results indicate that Plcg1 functions specifically downstream of the Vegf receptor during embryonic development to govern formation of the arterial system.

引用

页码：1346 / 1351

页数：6

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