Bilateral retinal vein occlusion associated with 5,10-methylenetetrahydrofolate reductase mutation

被引:26
作者
Loewenstein, A [1 ]
Winder, A [1 ]
Goldstein, M [1 ]
Lazar, M [1 ]
Eldor, A [1 ]
机构
[1] TEL AVIV MED CTR & SCH MED,INST HEMATOL,IL-64239 TEL AVIV,ISRAEL
关键词
D O I
10.1016/S0002-9394(14)71703-9
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To report on the occurrence of 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency, known to cause mild to moderate hyperhomocystinemia and increased risk of vascular occlusive disease, in a young patient with bilateral central retinal vein occlusion. METHODS: A 25-year-old man was initially examined with central retinal vein occlusion in the right-eye, followed 4 months later by a central retinal vein occlusion in the left eye. Studies for risk factors predisposing to thrombosis were performed. RESULTS: Hematologic studies failed to detect any pathology, However, the patient was found to be homozygous for 677C-T mutation in MTHFR enzyme. CONCLUSION: Central retinal vein occlusion may be associated with a mutation in MTHFR.
引用
收藏
页码:840 / 841
页数:2
相关论文
共 5 条
[1]   HYPERHOMOCYSTEINEMIA - AN INDEPENDENT RISK FACTOR FOR VASCULAR-DISEASE [J].
CLARKE, R ;
DALY, L ;
ROBINSON, K ;
NAUGHTEN, E ;
CAHALANE, S ;
FOWLER, B ;
GRAHAM, I .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (17) :1149-1155
[2]   Hyperhomocysteinemia as a risk factor for deep-vein thrombosis [J].
denHeijer, M ;
Koster, T ;
Blom, HJ ;
Bos, GMJ ;
Briet, E ;
Reitsma, PH ;
Vandenbroucke, JP ;
Rosendaal, FR .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (12) :759-762
[3]   TREATMENT OF MILD HYPERHOMOCYSTEINEMIA IN VASCULAR-DISEASE PATIENTS [J].
FRANKEN, DG ;
BOERS, GHJ ;
BLOM, HJ ;
TRIJBELS, FJM ;
KLOPPENBORG, PWC .
ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (03) :465-470
[4]  
Kluijtmans LAJ, 1996, AM J HUM GENET, V58, P35
[5]   THE ROLE OF ABNORMALITIES IN THE ANTICOAGULANT AND FIBRINOLYTIC SYSTEMS IN RETINAL VASCULAR OCCLUSIONS [J].
VINE, AK ;
SAMAMA, MM .
SURVEY OF OPHTHALMOLOGY, 1993, 37 (04) :283-292