Angiotensin-(1-7): an update

被引：340

作者：

Santos, RAS ^{[1
]}

Campagnole-Santos, MJ ^{[1
]}

Andrade, SP ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil

来源：

REGULATORY PEPTIDES | 2000年 / 91卷 / 1-3期

关键词：

renin-angiotensin system; multiple mediator system; angiotensin-(1-7);

D O I：

10.1016/S0167-0115(00)00138-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several actions of the RAS. In this article we will review our knowledge of the biological actions of Ang-(1-7) with focus on the puzzling aspects of the mediation of its effects and the interaction Ang-(1-7)-kinins. In addition, we will attempt to summarize the evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：45 / 62

页数：18

共 230 条

[1] Angiotensin-(1-7) induces bradykinin-mediated hypotensive responses in anesthetized rats [J].

Abbas, A ;

Gorelik, G ;

Carbini, LA ;

Scicli, AG .

HYPERTENSION, 1997, 30 (02) :217-221

[2] ANGIOTENSIN RECEPTOR-BINDING AND PRESSOR EFFECTS IN CAT SUBRETROFACIAL NUCLEUS [J].

ALLEN, AM ;

DAMPNEY, RAL ;

MENDELSOHN, FAO .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :H1011-H1017

[3]

ALMEIDA AP, 2000, IN PRESS BRAZ J MOL

[4] [7-D-ALA]-ANGIOTENSIN-(1-7) - SELECTIVE ANTAGONISM OF ANGIOTENSIN-(1-7) IN THE RAT PARAVENTRICULAR NUCLEUS [J].

AMBUHL, P ;

FELIX, D ;

KHOSLA, MC .

BRAIN RESEARCH BULLETIN, 1994, 35 (04) :289-291

[5] EFFECTS OF ANGIOTENSIN ANALOGS AND ANGIOTENSIN RECEPTOR ANTAGONISTS ON PARAVENTRICULAR NEURONS [J].

AMBUHL, P ;

FELIX, D ;

IMBODEN, H ;

KHOSLA, MC ;

FERRARIO, CM .

REGULATORY PEPTIDES, 1992, 38 (02) :111-120

[6] Angiotensin-II-induced angiogenesis in sponge implants in mice [J].

Andrade, SP ;

Cardoso, CC ;

Machado, RDP ;

Beraldo, WT .

INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL, 1996, 16 (06) :302-307

[7]

ANDREATTA SH, 1988, HYPERTENSION, V11, P163

[8] MODULATION OF PHOSPHOLIPASE-A2 ACTIVITY AND SODIUM-TRANSPORT BY ANGIOTENSIN-(1-7) [J].

ANDREATTAVANLEYEN, S ;

ROMERO, MF ;

KHOSLA, MC ;

DOUGLAS, JG .

KIDNEY INTERNATIONAL, 1993, 44 (05) :932-936

[9]

Ardaillou R, 1999, J AM SOC NEPHROL, V10, pS30

[10] Active fragments of angiotensin II: Enzymatic pathways of synthesis and biological effects [J].

Ardaillou, R .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1997, 6 (01) :28-34

← 1 2 3 4 5 6 7 8 9 10 →