Development of a liposome based contraceptive system for intravaginal administration of progesterone

Progesterone bearing liposomes were prepared by the cast film method and characterized for various physical attributes. The liposomes could encapsulate nearly 98% of the drug. The progesterone bearing liposomes were incorporated into polyacrylamide gel and the drug content was determined. The in vitro drug diffusion across she-goat vaginal membrane from the liposomal formulation was found to follow near zero order kinetics. The progestational activity of liposomal and central gel was assessed by monitoring the effect on the formation of corpora lutea. It was observed that both the formulations inhibit the formation of corpora lutea and thus, exhibited progestational activity but the effect of liposomal preparation was found to be greater and prolonged as compare to control gel.