Flipping the switch: The structural basis for signaling through the CRIB motif

被引：60

作者：

Hoffman, GR

Cerione, RA ^{[1
]}

机构：

[1] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Mol Med, Ithaca, NY 14853 USA

来源：

CELL | 2000年 / 102卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(00)00045-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：403 / 406

页数：4

共 19 条

[1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].

Abdul-Manan, N ;

Aghazadeh, B ;

Liu, GA ;

Majumdar, A ;

Ouerfelli, O ;

Siminovitch, KA ;

Rosen, MK .

NATURE, 1999, 399 (6734) :379-383

[2] PAK to the future [J].

Bagrodia, S ;

Cerione, RA .

TRENDS IN CELL BIOLOGY, 1999, 9 (09) :350-355

[3] Actin polymerization: Where the WASP stings [J].

Bi, EF ;

Zigmond, SH .

CURRENT BIOLOGY, 1999, 9 (05) :R160-R163

[4] A CONSERVED BINDING MOTIF DEFINES NUMEROUS CANDIDATE TARGET PROTEINS FOR BOTH CDC42 AND RAC GTPASES [J].

BURBELO, PD ;

DRECHSEL, D ;

HALL, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (49) :29071-29074

[5] Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members [J].

Frost, JA ;

Xu, SC ;

Hutchison, MR ;

Marcus, S ;

Cobb, MH .

MOLECULAR AND CELLULAR BIOLOGY, 1996, 16 (07) :3707-3713

[6] Structure of the complex of Cdc42Hs with a peptide derived from p-21 activated kinase [J].

Gizachew, D ;

Guo, W ;

Chohan, KK ;

Sutcliffe, MJ ;

Oswald, RE .

BIOCHEMISTRY, 2000, 39 (14) :3963-3971

[7] Active and inactive protein kinases: Structural basis for regulation [J].

Johnson, LN ;

Noble, MEM ;

Owen, DJ .

CELL, 1996, 85 (02) :149-158

[8] Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein [J].

Kim, AS ;

Kakalis, LT ;

Abdul-Manan, M ;

Liu, GA ;

Rosen, MK .

NATURE, 2000, 404 (6774) :151-158

[9] Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch [J].

Lei, M ;

Lu, WG ;

Meng, WY ;

Parrini, MC ;

Eck, MJ ;

Mayer, BJ ;

Harrison, SC .

CELL, 2000, 102 (03) :387-397

[10] A NONRECEPTOR TYROSINE KINASE THAT INHIBITS THE GTPASE ACTIVITY OF P21(CDC42) [J].

MANSER, E ;

LEUNG, T ;

SALIHUDDIN, H ;

TAN, L ;

LIM, L .

NATURE, 1993, 363 (6427) :364-367

← 1 2 →