Metabolic adaptation of mice in a cool environment

被引:27
作者
Uchida, Kunitoshi [1 ,2 ]
Shiuchi, Tetsuya [2 ,3 ]
Inada, Hitoshi [1 ]
Minokoshi, Yasuhiko [2 ,3 ]
Tominaga, Makoto [1 ,2 ]
机构
[1] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Natl Inst Physiol Sci, Div Cell Signaling, Okazaki, Aichi 4448787, Japan
[2] Grad Univ Adv Studies, Dept Physiol Sci, Aichi, Japan
[3] Natl Inst Physiol Sci, Div Endocrinol & Metab, Aichi, Japan
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2010年 / 459卷 / 05期
关键词
Cool environment; Glucose metabolism; Fat storage; White adipose tissue; Sympathetic nervous activity; BROWN ADIPOSE-TISSUE; COLD-EXPOSURE; SEASONAL-VARIATION; GLUCOSE-UPTAKE; INSULIN; THERMOGENESIS; RATS; FAT; MODULATION; ADIPOCYTE;
D O I
10.1007/s00424-010-0795-3
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Homeothermic animals, including humans, live by adapting to changes in ambient temperature. Numerous studies have demonstrated cold exposure (at approximately 5A degrees C) improves glucose tolerance despite reducing insulin secretion and increasing energy expenditure. To determine the effects of a small reduction in ambient temperature on energy metabolism, we compared two groups of mice; one exposed to a cool environment (20A degrees C) and the other maintained in a near-thermoneutral environment (25A degrees C) for 10 days. Both glucose-induced insulin secretion and glucose response were significantly impaired in mice exposed to a cool environment. In the cool temperature-exposed mice, skin temperatures were reduced, and plasma norepinephrine levels were increased, suggesting that impairment of insulin secretion was facilitated by induction of sympathetic nervous activity due to skin cooling. In addition, expression of GLUT4 mRNA was increased significantly in inguinal subcutaneous adipose tissue (IWAT) but not in epididymal or brown adipose tissue or skeletal muscle in these mice. Moreover, expression of Dok1, a molecule linked to activation of insulin receptors in adipocyte hypertrophy, and Cd36, a molecule related to NEFA uptake, were also increased at mRNA and/or protein levels only in IWAT of the cool temperature-exposed mice. Fatty acid synthesis was also facilitated, and fat weights were increased only in IWAT from mice kept at 20A degrees C. These results suggest that a small reduction in ambient temperature can affect glucose homeostasis through regulation of insulin secretion and preferentially enhances fat storage in IWAT. These adaptations can be interpreted as preparation for a further reduction in ambient temperature.
引用
收藏
页码:765 / 774
页数:10
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