Trace voltammetric measurements of cancerostatic actinomycin-C1

被引：6

作者：

Ibrahim, MS

Temerk, YM

机构：

[1] United Arab Emirates Univ, Fac Sci, Dept Chem, Al Ain, U Arab Emirates

[2] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt

来源：

ANALUSIS | 1998年 / 26卷 / 03期

关键词：

actinomycin-C1; stripping voltammetry; hanging mercury drop electrode;

D O I：

10.1051/analusis:1998125

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Adsorptive accumulation in stripping voltammetry has been applied for trace measurements of the cancerostatic drug actinomycin-Cl (ACT). Accumulation is achieved by controlled adsorption of ACT film on the hanging mercury drop electrode (HMDE). The cathodic stripping response was evaluated with respect to accumulation time, concentration dependence, solution conditions and other variables. The limit of detection after 5 minutes preconcentration is 1 mu g L-1 (8 x 10(-10) M). The effects of possible interferences, due to coexisting metal ions or organic substances, are evaluated. The applicability of the method to the determination of ACT in untreated urine is described.

引用

页码：145 / 149

页数：5

共 26 条

[1]

AHMED ZA, 1994, ANALUSIS, V22, P82

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