Cognitive dysfunction in patients with obstructive sleep apnea (OSA): partial reversibility after continuous positive airway pressure (CPAP)

被引:256
作者
Ferini-Strambi, L [1 ]
Baietto, C [1 ]
Di Gioia, MR [1 ]
Castaldi, P [1 ]
Castronovo, C [1 ]
Zucconi, M [1 ]
Cappa, SR [1 ]
机构
[1] Univ Vita Salute San Raffaele, Sleep Disorders Ctr, I-20127 Milan, Italy
关键词
cognitive function; sleep apnea; sleepiness;
D O I
10.1016/S0361-9230(03)00068-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aims of this study were to assess cognitive function in obstructive sleep apnea (OSA) patients and to evaluate the effect of short- and long-term treatment with continuous positive airway pressure treatment (CPAP). A battery of neuropsychological tests, the Epworth Sleepiness Scale (ESS), and the Beck Inventory Scale were administered to 23 patients with severe OSA (age: 56.5 +/- 6.13; AHI: 54.9 +/- 13.37) and to 23 age- and education-matched controls. The OSA patients were evaluated in a baseline condition and in two follow-up treatment sessions (after 15 days and 4 months of CPAP, respectively). At baseline, OSA patients had a significant impairment, compared to controls, in tests of sustained attention, visuospatial learning, executive function, motor performance, and constructional abilities. The longitudinal evaluation showed that after a 15-days CPAP treatment attentive, visuospatial learning, and motor performances returned to normal levels. A 4-months CPAP treatment did not result in any further improvement in cognitive tests. Performance on tests evaluating executive functions and constructional abilities was not affected by short- and long-term treatment with CPAR The findings of this study confirm the hypothesis of partial reversibility of cognitive dysfunction in OSA patients after CPAR (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:87 / 92
页数:6
相关论文
共 43 条
[1]   Neuropsychological effects of one-week continuous positive airway pressure treatment in patients with obstructive sleep apnea: A placebo-controlled study [J].
Bardwell, WA ;
Ancoli-Israel, S ;
Berry, CC ;
Dimsdale, JE .
PSYCHOSOMATIC MEDICINE, 2001, 63 (04) :579-584
[2]   Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits [J].
Beebe, DW ;
Gozal, D .
JOURNAL OF SLEEP RESEARCH, 2002, 11 (01) :1-16
[3]  
BERARD MA, 1991, J CLIN EXP NEUROPSYC, V13, P950
[4]  
BERARD MA, 1993, J CLIN EXP NEUROPSYC, V15, P330
[5]  
BERARD MA, 1991, CHEST, V100, P367
[6]   NOCTURNAL HYPOXIA AND NEUROPSYCHOLOGICAL VARIABLES [J].
BERRY, DTR ;
WEBB, WB ;
BLOCK, AJ ;
BAUER, RM ;
SWITZER, DA .
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1986, 8 (03) :229-238
[7]   SLEEP-APNEA AND COGNITIVE FUNCTION - WHERE DO WE STAND NOW [J].
BLIWISE, DL .
SLEEP, 1993, 16 (08) :S72-S73
[8]   FACTORS IMPAIRING DAYTIME PERFORMANCE IN PATIENTS WITH SLEEP-APNEA HYPOPNEA SYNDROME [J].
CHESHIRE, K ;
ENGLEMAN, H ;
DEARY, I ;
SHAPIRO, C ;
DOUGLAS, NJ .
ARCHIVES OF INTERNAL MEDICINE, 1992, 152 (03) :538-541
[9]  
Davis J N, 1979, Adv Neurol, V26, P219
[10]  
Doran SM, 2001, ARCH ITAL BIOL, V139, P253