Increased CSF tau protein in corticobasal degeneration

被引：3

作者：

Mitani, K

Furiya, Y

Uchihara, T

Ishii, K

Yamanouchi, H

Mizusawa, H

Mori, H

机构：

[1] Tokyo Metropolitan Inst Neurosci, Dept Neuropathol, Tokyo 183, Japan

[2] Tokyo Metropolitan Inst Gerontol, Dept Neurol, Itabashi Ku, Tokyo 173, Japan

[3] Tokyo Inst Psychiat, Dept Mol Biol, Setagaya Ku, Tokyo 168, Japan

[4] Tokyo Med & Dent Univ, Dept Neurol, Bunkyo Ku, Tokyo 113, Japan

来源：

JOURNAL OF NEUROLOGY | 1998年 / 245卷 / 01期

关键词：

tau; corticobasal degeneration; cerebrospinal fluid; sandwich ELISA;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Using a sensitive sandwich enzyme-linked immunosorbent assay (ELISA) method, we measured the concentration of total tau protein in the cerebrospinal fluid (CSF) from nine patients with corticobasal degeneration (CBD) in comparison with 12 normal control subjects in order to assess its diagnostic value. The CSF concentration of tau in patients with C-BD (0.69, 0.20 ng/ml: mean, SD) was higher than that in the normal controls (0.48, 0.14 ng/ml, P = 0.0076 unpaired t test). This increase in CBD patients may reflect widespread tau pathology in CBD, but should be interpreted with reserve as an aid to diagnosis.

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页码：44 / 46

页数：3

相关论文

共 27 条

[1]

TAU IN CEREBROSPINAL-FLUID - A POTENTIAL DIAGNOSTIC MARKER IN ALZHEIMERS-DISEASE [J].

ARAI, H ;

TERAJIMA, M ;

MIURA, L ;

HIGUCHI, S ;

MURAMATSU, T ;

MACHIDA, N ;

SEIKI, H ;

TAKASE, S ;

CLARK, CM ;

LEE, VMY ;

TROJANOWSKI, JQ ;

SASAKI, H .

ANNALS OF NEUROLOGY, 1995, 38 (04) :649-652

[2]

BRAMBLETT GT, 1992, LAB INVEST, V66, P212

[3]

CHANGES IN A CSF ANTIGEN ASSOCIATED WITH DEMENTIA [J].

CARRETERO, MT ;

HARRINGTON, CR ;

WISCHIK, CM .

DEMENTIA, 1995, 6 (05) :281-285

[4]

PATHOLOGICAL TAU-PROTEINS OF ALZHEIMERS-DISEASE AS A BIOCHEMICAL MARKER OF NEUROFIBRILLARY DEGENERATION [J].

DELACOURTE, A .

BIOMEDICINE & PHARMACOTHERAPY, 1994, 48 (07) :287-295

[5]

Specific pathological Tau protein variants characterize Pick's disease [J].

Delacourte, A ;

Robitaille, Y ;

Sergeant, N ;

Buee, L ;

Hof, PR ;

Wattez, A ;

LarocheCholette, A ;

Mathieu, J ;

Chagnon, P ;

Gauvreau, D .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (02) :159-168

[6]

FEANY MB, 1995, ACTA NEUROPATHOL, V90, P37

[7]

Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration [J].

Feany, MB ;

Mattiace, LA ;

Dickson, DW .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (01) :53-67

[8]

FEANY MB, 1995, AM J PATHOL, V146, P1388

[9]

BIOCHEMICAL ASSAY OF ALZHEIMERS-DISEASE ASSOCIATED PROTEIN(S) IN HUMAN BRAIN-TISSUE - A CLINICAL-STUDY [J].

GHANBARI, HA ;

MILLER, BE ;

HAIGLER, HJ ;

ARATO, M ;

BISSETTE, G ;

DAVIES, P ;

NEMEROFF, CB ;

PERRY, EK ;

PERRY, R ;

RAVID, R ;

SWAAB, DF ;

WHETSELL, WO ;

ZEMLAN, FP .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (21) :2907-2910

[10]

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans [J].

Goedert, M ;

Jakes, R ;

Spillantini, MG ;

Hasegawa, M ;

Smith, MJ ;

Crowther, RA .

NATURE, 1996, 383 (6600) :550-553