Comparison of seizure. duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT

被引：98

作者：

Krystal, AD ^{[1
]}

Weiner, RD ^{[1
]}

Dean, MD ^{[1
]}

Lindahl, VH ^{[1
]}

Tramontozzi, LA ^{[1
]}

Falcone, G ^{[1
]}

Coffey, CE ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1176/appi.neuropsych.15.1.27

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors retrospectively compared the seizure duration, ictal EEG, and cognitive side effects of ketamine and methohexital anesthesia with ECT. This comparison was carried out with data from consecutive index ECT treatments that occurred immediately before and after a switch from methohexital to ketamine in 36 patients. Ketamine was well tolerated and prolonged seizure duration overall, but particularly in those who had a seizure duration shorter than 25 seconds with methohexital at the maximum available stimulus intensity. Ketamine also increased midictal EEG slow-wave amplitude. Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects.

引用

页码：27 / 34

页数：8

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