Thalassemia: current approach to an old disease

被引：36

作者：

Lo, L ^{[1
]}

Singer, ST ^{[1
]}

机构：

[1] Childrens Hosp & Res Ctr, Dept Hematol Oncol, Oakland, CA 94069 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2002年 / 49卷 / 06期

关键词：

D O I：

10.1016/S0031-3955(02)00088-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This article discusses the approach for recognition, diagnosis, and management of the thalassemias, and reviews new prospects of therapy, focusing mostly on the beta-thalassemias-the more severe and clinically important type. beta-thalassemia major is typically treated with regular transfusion and chelation therapy. New strategies for specific therapy including monitoring of iron induced organ damage, fetal hemoglobin augmentation as an alternative for transfusions, bone marrow transplantation offer hope for prevention of complications and better care of the beta-thalassemias.

引用

页码：1165 / +

页数：28

共 116 条

[1] Cardiac involvement in thalassemia intermedia: a multicenter study [J].

Aessopos, A ;

Farmakis, D ;

Karagiorga, M ;

Voskaridou, E ;

Loutradi, A ;

Hatziliami, A ;

Joussef, J ;

Rombos, J ;

Loukopoulos, D .

BLOOD, 2001, 97 (11) :3411-3416

[2] The role of partial splenectomy in children with thalassemia [J].

Al-Salem, AH ;

Al-Dabbous, I ;

Bhamidibati, P .

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, 1998, 8 (06) :334-338

[3] α+-thalassemia protects children against disease caused by other infections as well as malaria [J].

Allen, SJ ;

O'Donnell, A ;

Alexander, NDE ;

Alpers, MP ;

Peto, TEA ;

Clegg, JB ;

Weatherall, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14736-14741

[4]

ALTER BP, 1990, ANN NY ACAD SCI, V612, P237

[5] Global epidemiology of hemoglobin disorders [J].

Angastiniotis, M ;

Modell, B .

COOLEYS ANEMIA: SEVENTH SYMPOSIUM, 1998, 850 :251-269

[6]

ANGELUCCI E, 1994, HAEMATOLOGICA, V79, P353

[7] Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation [J].

Angelucci, E ;

Muretto, P ;

Lucarelli, G ;

Ripalti, M ;

Baronciani, D ;

Erer, B ;

Galimberti, M ;

Giardini, C ;

Gaziev, D ;

Polchi, P ;

Rovelli, A ;

Monguzzi, W ;

Masera, G ;

Piga, A ;

Garofalo, F ;

Gabutti, V ;

DiGregorio, F ;

Romeo, MA ;

Cammella, A ;

Russo, G ;

Gallisai, D ;

Burrai, C ;

Costi, C ;

Marinaro, AM ;

Erbeia, M ;

Mazzani, D ;

Nobili, B ;

Perrotta, S ;

Ferrara ;

Cutillo, S ;

Mulas, G ;

Careddu, F ;

Mancini, E ;

Argiolu, F ;

Addari, C ;

Ruggiero, L ;

DeNunzio, A ;

Terzoli, S ;

DAscola, G ;

Bruciatelli, M ;

Satta, AM ;

BorgnaPignatti, C ;

Marradi, P ;

Puggioni, G ;

Murgia, T ;

Porta, E ;

Poggi, V ;

PintaBoccalatte, MF ;

Polizzi, B ;

Maroni, P .

BLOOD, 1997, 90 (03) :994-998

[8]

[Anonymous], 1925, Trans Am Pediatr Soc

[9]

Bonkovsky H L, 2000, Clin Liver Dis, V4, P409, DOI 10.1016/S1089-3261(05)70116-1

[10] Survival and disease complications in thalassemia major [J].

Borgna-Pignatti, C ;

Rugolotto, S ;

De Stefano, P ;

Piga, A ;

Di Gregorio, F ;

Gamberini, MR ;

Sabato, V ;

Melevendi, C ;

Cappellini, MD ;

Verlato, G .

COOLEYS ANEMIA: SEVENTH SYMPOSIUM, 1998, 850 :227-231

← 1 2 3 4 5 6 7 8 9 10 →