Enantioselective isomerization of allylamine to enamine: practical asymmetric synthesis of (-)-menthol by Rh-BINAP catalysts

被引：46

作者：

Akutagawa, S ^{[1
]}

机构：

[1] Takasago Int Corp, Minato Ku, Tokyo 108, Japan

来源：

TOPICS IN CATALYSIS | 1997年 / 4卷 / 3-4期

关键词：

allylamine; asymmetric synthesis; BINAP; chiral ligand; homogeneous catalysis; isomerization; isoprenoid amine; (-)-menthol; rhodium;

D O I：

10.1023/A:1019112911246

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Enantioselective isomerizations of allylamines to enamines are summarized from idea to industry. The Rh-BINAP catalyst reveals high selectivities, 99% yield and 98% enantiomer excess and high activity, TON > 400,000. Its industrial use for the production of a 1,500 t/y scale of (-)-menthol is introduced emphasizing technical development.

引用

页码：271 / 274

页数：4

共 9 条

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