Remote Ischemic Conditioning in Cardiovascular Surgery: Still a Viable and Realistic Option?

被引：22

作者：

Heusch, Gerd ^{[1
]}

机构：

[1] Univ Essen Gesamthsch, Sch Med, West German Heart & Vasc Ctr, Inst Pathophysiol, Essen, Germany

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS | 2017年 / 22卷 / 04期

关键词：

ischemic heart disease; myocardial ischemia; reperfusion; cardioprotection; CARDIAC BYPASS-SURGERY; CLINICAL-TRIAL; CORONARY REVASCULARIZATION; REPERFUSION INJURY; MYOCARDIAL INJURY; NERVOUS-SYSTEM; GRAFT-SURGERY; CARDIOPROTECTION; PROTECTION; PROPOFOL;

D O I：

10.1177/1074248416687874

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The existing clinical studies on remote ischemic preconditioning in patients undergoing cardiovascular surgery are critically reviewed, with a focus on infarct size reduction and clinical outcome as end points. Confounders, notably the use of propofol anesthesia are identified. The need for better designed trials with a more targeted approach is emphasized.

引用

页码：297 / 301

页数：5

共 36 条

[1]

Bautin A. E., 2014, Anesteziologiya i Reanimatologiya, P11

[2]

Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial [J].

Candilio, Luciano ;

Malik, Abdul ;

Ariti, Cono ;

Barnard, Matthew ;

Di Salvo, Carmelo ;

Lawrence, David ;

Hayward, Martin ;

Yap, John ;

Roberts, Neil ;

Sheikh, Amir ;

Kolvekar, Shyam ;

Hausenloy, Derek J. ;

Yellon, Derek M. .

HEART, 2015, 101 (03) :185-192

[3]

Role of the parasympathetic nervous system in cardioprotection by remote hindlimb ischaemic preconditioning [J].

Donato, Martin ;

Buchholz, Bruno ;

Rodriguez, Manuel ;

Perez, Virginia ;

Inserte, Javier ;

Garcia-Dorado, David ;

Gelpi, Ricardo J. .

EXPERIMENTAL PHYSIOLOGY, 2013, 98 (02) :425-434

[4]

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning [J].

Ferdinandy, Peter ;

Hausenloy, Derek J. ;

Heusch, Gerd ;

Baxter, Gary F. ;

Schulz, Rainer .

PHARMACOLOGICAL REVIEWS, 2014, 66 (04) :1142-1174

[5]

Remote Ischemic Conditioning and the Long Road to Clinical Translation Lessons Learned From ERICCA and RIPHeart [J].

Garratt, Kirk N. ;

Whittaker, Peter ;

Przyklenk, Karin .

CIRCULATION RESEARCH, 2016, 118 (07) :1052-1054

[6]

The Effect of Remote Ischemic Conditioning and Glyceryl Trinitrate on Perioperative Myocardial Injury in Cardiac Bypass Surgery Patients: Rationale and Design of the ERIC-GTN Study [J].

Hamarneh, Ashraf ;

Sivaraman, Vivek ;

Bulluck, Heerajnarain ;

Shanahan, Hilary ;

Kyle, Bonnie ;

Ramlall, Manish ;

Chung, Robin ;

Jarvis, Claire ;

Xenou, Maria ;

Ariti, Cono ;

Cordery, Roger ;

Yellon, Derek M. ;

Hausenloy, Derek J. .

CLINICAL CARDIOLOGY, 2015, 38 (11) :641-646

[7]

Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery [J].

Hausenloy, D. J. ;

Candilio, L. ;

Evans, R. ;

Ariti, C. ;

Jenkins, D. P. ;

Kolvekar, S. ;

Knight, R. ;

Kunst, G. ;

Laing, C. ;

Nicholas, J. ;

Pepper, J. ;

Robertson, S. ;

Xenou, M. ;

Clayton, T. ;

Yellon, D. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (15) :1408-1417

[8]

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial [J].

Hausenloy, Derek J. ;

Mwamure, Peter K. ;

Venugopal, Vinod ;

Harris, Joanne ;

Barnard, Matthew ;

Grundy, Ernie ;

Ashley, Elizabeth ;

Vichare, Sanjeev ;

Di Salvo, Carmelo ;

Kolvekar, Shyam ;

Hayward, Martin ;

Keogh, Bruce ;

MacAllister, Raymond J. ;

Yellon, Derek M. .

LANCET, 2007, 370 (9587) :575-579

[9]

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge [J].

Heusch, Gerd ;

Gersh, Bernard J. .

EUROPEAN HEART JOURNAL, 2017, 38 (11) :774-+

[10]

Time to Give Up on Cardioprotection?: A Critical Appraisal of Clinical Studies on Ischemic Pre-, Post-, and Remote Conditioning* [J].

Heusch, Gerd ;

Rassaf, Tienush .

CIRCULATION RESEARCH, 2016, 119 (05) :676-695

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