Remodeling of second-order neurons in the retina of rd/rd mutant mice

被引：188

作者：

Strettoi, E

Pignatelli, V

Rossi, C

Porciatti, V

Falsini, B

机构：

[1] CNR, Ist Neurosci, Lab Neurofisiol, I-56100 Pisa, Italy

[2] Bascom Palmer Eye Inst, Miami, FL 33136 USA

[3] Univ Cattolica Sacro Cuore, Clin Oculistica, I-00168 Rome, Italy

来源：

VISION RESEARCH | 2003年 / 43卷 / 08期

关键词：

bipolar cell; dendritic atrophy; horizontal cells; ERG; retinitis pigmentosa;

D O I：

10.1016/S0042-6989(02)00594-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This is a brief review of data obtained by analyzing the morphology and the physiology of the retinas in rd/rd and normal, wt mice, aged 10-90 days. Second-order neurons of the rd/rd show abnormalities that start with the anomalous development of rod bipolar cells around P10 and culminate with the atrophy of dendrites in cone bipolar cells, mostly evident at P90. Horizontal cells remodel considerably. Cone-mediated ERGs, (recorded between 13 and 16 days of age) have reduced a-wave and b-wave amplitudes and longer b-wave latency and duration. B-wave abnormalities indicate specific postreceptoral dysfunction. Morphological and ERG changes in rd/rd retinas are consistent with substantial inner retinal remodeling associated to photoreceptor degeneration. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：867 / 877

页数：11

共 53 条

[1] Gene therapy restores vision in a canine model of childhood blindness [J].