The role of female hormonal factors in the development of rheumatoid arthritis

被引：126

作者：

Alpizar-Rodriguez, Deshire ^{[1
]}

Pluchino, Nicola ^{[2
,3
]}

Canny, Geraldine ^{[4
]}

Gabay, Cem ^{[1
]}

Finckh, Axel ^{[1
]}

机构：

[1] Univ Hosp Geneva, Dept Internal Med Specialties, Div Rheumatol 3, Geneva, Switzerland

[2] Univ Hosp Geneva, Dept Obstet & Gynecol, Div Gynecol, Geneva, Switzerland

[3] Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT USA

[4] Ecole Polytech Fed Lausanne, Dept Res Affairs, Lausanne, Switzerland

来源：

RHEUMATOLOGY | 2017年 / 56卷 / 08期

关键词：

rheumatoid arthritis; women's health; risk factors; female hormonal factors; reproductive factors; CYCLIC CITRULLINATED PEPTIDE; REPRODUCTIVE RISK-FACTORS; ORAL-CONTRACEPTIVES; SYNOVIAL-FLUID; T-CELL; ESTROGEN FORMATION; ANDROGEN RATIO; WOMEN; SEX; AUTOIMMUNE;

D O I：

10.1093/rheumatology/kew318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity. As some female hormonal factors may be potentially modifiable, understanding their impact on RA development is clinically relevant and may result in specific preventive interventions in high-risk populations.

引用

页码：1254 / 1263

页数：10

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