The epithelial mucin, MUC1, is expressed on resting T lymphocytes and can function as a negative regulator of T cell activation

被引:48
作者
Chang, JF [1 ]
Zhao, HL [1 ]
Phillips, J [1 ]
Greenburg, G [1 ]
机构
[1] Cell Genesys Inc, Foster City, CA 94404 USA
关键词
MUC1; T-lymphocyte; tumor-associated antigen; DF3-P; negative regulation;
D O I
10.1006/cimm.2000.1643
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
MUC1 is a mucinous glycoprotein which is normally expressed on the surface of a variety of epithelia and aberrantly overexpressed on some human tumors. In this report, we demonstrate that the epithelial mucin, MUC1, is expressed on resting human peripheral blood T cells and two leukemia T cell lines, Jurkat and Hut 78. Crosslinking of MUC1 on peripheral blood T cells by plate-bound anti-MUC1 (DF3-P) antibody inhibits cell proliferation, IL-2 and GM-CSF production, and up-regulation of the IL-2 receptor upon anti-CD3 stimulation. Induction of IL-2 production by Jurkat and HUT 78 is also suppressed and cannot be reversed by the addition of anti-CD28 mAb. These findings suggest that MUC1 can be a potent negative regulator for T cell activation at the resting stage. (C) 2000 Academic Press.
引用
收藏
页码:83 / 88
页数:6
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