Protein Degradation, Aggregation, and Misfolding

被引：94

作者：

Cuervo, Ana Maria ^{[1
]}

Wong, Esther S. P.

Martinez-Vicente, Marta

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA

来源：

MOVEMENT DISORDERS | 2010年 / 25卷 / 03期

关键词：

autophagy; lysosomes; neurodegeneration; protein aggregates; proteases; ALPHA-SYNUCLEIN; AUTOPHAGY; DISEASE; NEURODEGENERATION; UBIQUITINATION; SYNPHILIN-1; DISRUPTION; AGGRESOMES; CLEARANCE; MODELS;

D O I：

10.1002/mds.22718

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease. (C) 2010 Movement Disorder Society

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收藏

页码：S49 / S54

页数：6

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