Microbial biotransformation of veratramine

被引:21
作者
El Sayed, KA [1 ]
机构
[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Mississippi State, MS 38677 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期
关键词
D O I
10.1021/np9703611
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Preparative-scale fermentation of the known C-nor-D-homosteroidal alkaloid veratramine (1) with Nocardia species ATCC 21145 has resulted in the isolation of three new metabolites, 2-4. The structure elucidation of these compounds was conducted primarily by 2D NMR analysis. The microbe Nocardia species ATCC 21145 was able to metabolize rings A and B of veratramine but failed to metabolize its nitrogen-containing side chain, an observation consistent with previous fermentation studies on steroidal alkaloids.
引用
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页码:149 / 151
页数:3
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