Elevated plasma concentrations of lipoprotein(a) in medicated epileptic patients

被引：51

作者：

Schwaninger, M

Ringleb, P

Annecke, A

Winter, R

Kohl, B

Werle, E

Fiehn, V

Rieser, PA

Waiter-Sack, I

机构：

[1] Univ Heidelberg, Dept Neurol, D-69120 Heidelberg, Germany

[2] Univ Heidelberg, Dept Internal Med, D-69115 Heidelberg, Germany

[3] Heidelberger Druckmaschinen, Betriebsarztlicher Dienst, D-69115 Heidelberg, Germany

来源：

JOURNAL OF NEUROLOGY | 2000年 / 247卷 / 09期

关键词：

antiepileptic drugs; lipoprotein(a); arteriosclerosis; carotid intima media thickness;

D O I：

10.1007/s004150070111

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lipoprotein(a) [Lp(a)] has been identified as an independent risk factor for vascular diseases. There are no data on Lp(a) levels in patients on long-term medication with carbamazepine, phenytoin, phenobarbital, or valproate. To investigate the effects of such treatment on Lp(a) levels and common carotid artery intima media thickness we studied 51 epileptic outpatients on long-term antiepileptic medication and 51 age- and sex-matched controls. Lp(a) levels above 45 mg/dl were found in 11 of 50 patients, but in only 4 of 51 controls (P< 0.05). The mean serum concentration of Lp(a) was 33.0+/-7.0 mg/dl in patients and 16.9+/-2.7 mg/dl in controls (P< 0.05). Epileptic patients also had a thicker intima media of the common carotid artery (0.79+/-0.04 mm) than controls (0.69+/-0.02 mm, P< 0.05) as measured by B-mode ultrasonography. Our results suggest an untoward effect of long-term antiepileptic medication on Lp(a) serum concentrations. Elevated Lp(a) levels might be a risk factor for arteriosclerosis in epileptic patients.

引用

页码：687 / 690

页数：4

共 27 条

[1] Plasma lipoprotein(a) is an independent factor associated with carotid wall thickening in severely but not moderately hypercholesterolemic patients [J].