Ghrelin: a gastric peptide that regulates food intake and energy homeostasis

被引：107

作者：

Ueno, H

Yamaguchi, H

Kangawa, K

Nakazato, M ^{[1
]}

机构：

[1] Miyazaki Univ, Dept Internal Med 3, Miyazaki Med Coll, Miyazaki 8891692, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Osaka 3658586, Japan

来源：

REGULATORY PEPTIDES | 2005年 / 126卷 / 1-2期

关键词：

ghrelin; GH; GHS; GHS-R;

D O I：

10.1016/j.regpep.2004.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ghrelin, an endogenous ligand for the growth-hormione-secretagogue receptor, was isolated from human and rat stomach. It is a 28-amino acid peptide with a posttranslational acyl modification that is indispensable for its activity. In addition to stimulating growth-hormone, secretion, food intake, and body weight gain, ghrelin also plays a role in a variety of other systems, including circulation, digestion, and cell proliferation. This review will focus on the discovery, structural characteristics, tissue distribution, and physiological functions of ghrelin, as well as the regulation of its expression and secretion. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：11 / 19

页数：9

相关论文

共 68 条

[21] Role of ghrelin in streptozotocin-induced diabetic hyperphagia [J].

Ishii, S ;

Kamegai, J ;

Tamura, H ;

Shimizu, T ;

Sugihara, H ;

Oikawa, S .

ENDOCRINOLOGY, 2002, 143 (12) :4934-4937

[22] Chicken ghrelin: Purification, cDNA cloning, and biological activity [J].

Kaiya, H ;

Van Der Geyten, S ;

Kojima, M ;

Hosoda, H ;

Kitajima, Y ;

Matsumoto, M ;

Geelissen, S ;

Darras, VM ;

Kangawa, K .

ENDOCRINOLOGY, 2002, 143 (09) :3454-3463

[23] Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression [J].

Kamegai, J ;

Tamura, H ;

Shimizu, T ;

Ishii, S ;

Sugihara, H ;

Wakabayashi, I .

ENDOCRINOLOGY, 2000, 141 (12) :4797-4800

[24] Regulation of the ghrelin gene: Growth hormone-releasing hormone upregulates ghrelin mRNA in the pituitary [J].

Kamegai, J ;

Tamura, H ;

Shimizu, T ;

Ishii, S ;

Sugihara, H ;

Oikawa, S .

ENDOCRINOLOGY, 2001, 142 (09) :4154-4157

[25] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].

Kojima, M ;

Hosoda, H ;

Date, Y ;

Nakazato, M ;

Matsuo, H ;

Kangawa, K .

NATURE, 1999, 402 (6762) :656-660

[26] Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor [J].

Kojima, M ;

Hosoda, H ;

Matsuo, H ;

Kangawa, K .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2001, 12 (03) :118-122

[27] Ghrelin - a hormone with multiple functions [J].

Korbonits, M ;

Goldstone, AP ;

Gueorguiev, M ;

Grossman, AB .

FRONTIERS IN NEUROENDOCRINOLOGY, 2004, 25 (01) :27-68

[28] Ghrelin stimulates gastric acid secretion and motility in rats [J].

Masuda, Y ;

Tanaka, T ;

Inomata, N ;

Ohnuma, N ;

Tanaka, S ;

Itoh, Z ;

Hosoda, H ;

Kojima, M ;

Kangawa, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 276 (03) :905-908

[29] Structure-activity relationship of ghrelin: Pharmacological study of ghrelin peptides [J].

Matsumoto, M ;

Hosoda, H ;

Kitajima, Y ;

Morozumi, N ;

Minamitake, Y ;

Tanaka, S ;

Matsuo, H ;

Kojima, M ;

Hayashi, Y ;

Kangawa, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 287 (01) :142-146

[30] GROWTH-HORMONE SECRETAGOGUES - CHARACTERIZATION, EFFICACY, AND MINIMAL BIOACTIVE CONFORMATION [J].

MCDOWELL, RS ;

ELIAS, KA ;

STANLEY, MS ;

BURDICK, DJ ;

BURNIER, JP ;

CHAN, KS ;

FAIRBROTHER, WJ ;

HAMMONDS, RG ;

INGLE, GS ;

JACOBSEN, NE ;

MORTENSEN, DL ;

RAWSON, TE ;

WON, WB ;

CLARK, RG ;

SOMERS, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11165-11169

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